Apolipoprotein E genotypes of normal and hyperlipidemic subjects
نویسندگان
چکیده
منابع مشابه
Apolipoprotein E genotypes of normal and hyperlipidemic subjects.
Apolipoprotein E (apo E) plays a role in the regulation of the lipid metabolism of humans. Apo E, 229 amino acid polypeptide, is classified into three major isoform (E2, E3, E4) according to the differences of amino acid in position 112 and 158. In the normal population apo E3 isoform is most prevalent and apo E2 or E4 is frequently associated with hyperlipoproteinemia. To find out the frequenc...
متن کاملEnhanced apolipoprotein E production with normal hepatic mRNA levels in the Watanabe heritable hyperlipidemic rabbit.
The Watanabe heritable hyperlipidemic rabbit (WHHL) provides an experimental animal model for the low density lipoprotein (LDL) receptor defect present in patients homozygous for familial hypercholesterolemia (FH). Both WHHL rabbits and FH patients have a four- to sevenfold increase in plasma levels of apolipoprotein E (apo E). To determine the etiology for the elevated apo E concentrations, ki...
متن کاملIncreased plasma triglycerides, cholesterol and apolipoprotein E during prolonged fasting in normal subjects.
Plasma lipid and high density lipoprotein (HDL) levels were studied in 20 normal, healthy, non-obese males while fasting (150 kcal/d with free intake of water) for 6 d in a hunger strike. Plasma triglyceride and cholesterol levels were increased by 18% after 6 d of fasting. HDL-cholesterol concentration was not significantly changed for 4 d, but decreased by 22% after 6 d. Platelet aggregation ...
متن کاملAssociation of apolipoprotein E genotypes with prognosis in multiple sclerosis.
BACKGROUND Although the association between apolipoprotein E (APOE) genetic polymorphisms and multiple sclerosis (MS), has been debated, the presence of the epsilon4 allele has been associated with an aggressive disease progression. OBJECTIVES Present study aimed to investigate whether or not the APOE allele has an impact on disease progression in patients with MS. The study investigated the ...
متن کاملDetermination of apolipoprotein E genotypes by single-strand conformational polymorphism.
We used single-strand conformational polymorphism (SSCP) to determine apolipoprotein E (Apo E) genotypes in 47 individuals. A 295-base-pair (bp) DNA fragment coding for amino acid residues 80-178 of the Apo E protein gave distinct patterns for the three alleles. When we used SSCP to determine the Apo E polymorphism of five individuals whose phenotyping results differed from those of genotyping,...
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ژورنال
عنوان ژورنال: Journal of Korean Medical Science
سال: 1993
ISSN: 1011-8934,1598-6357
DOI: 10.3346/jkms.1993.8.4.262